​Love shared by a dog and a human is the pure joy of lying by each other, seeing each others' face after a few hours of departure, and running on each other's side. You love each other merely because of who you are and the bond you share. You are the center of her world, and she is the center of yours. She would be upset when she can't find you, and you would be anxious when she is hiding. You don't need to share common interests; maybe she can't talk about engineering with you, but she would put her head on your arm when you rumble. Her little head is so soft that it melts your heart. Maybe you are not such a great person, but she jumps on you every time she sees you. You don't need to be charming, funny, witty, smart when around her because she doesn't care, not like humans. She just cares if you are here with her, if you can rub her little tummy, if you are alive.

What a good feeling it is that you can care because you care and she cares back because she cares.  

--- To Ka'ala, my dog friend, who I love dearly

​https://rituraman.com/

Engineering Microrobots for targeted cancer therapies from a medical perspective

• "To overcome low targeting of conventional treatments, two major strategies exist that aim to achieve tumour-specific effects: systemic drugs that only affect cancer cells, and drugs that are specifically delivered into the tumour cells and/or their microenvironments. "
• "By contrast, solid tumours develop a higher-order tumour anatomy11, leading to different physical and biochemical microenvironments in the interior and exterior compartments (Fig. 2b). The increased requirement of oxygen of proliferating tumour cells is usually met by additional vascularisation to the exterior compartment of the tumour. Poor vascularisation inside the core region of the tumour, however, leads to a highly hypoxic core12,13. Low partial oxygen pressures force cancer cells residing in this area to generate energy via anaerobic, glycolytic pathways that lead to lactic acid generation and thus, acidic conditions inside the tumour core14. Moreover, owing to increased proliferation, limited space combined with abnormal blood and lymphatic networks increases the internal interstitial fluid pressure inside a tumour as it continues to grow, making it increasingly difficult to penetrate15."
• "nanocarriers can be coupled with targeting ligands including peptides, proteins, antibodies or aptamers2. The ligands recognise surface markers on cancer cells and can increase the active short-range targeting abilities of nanocarriers."
• "Cancer-fighting microrobots can be split into three major classes that can be distinguished based on their make-up and source of propulsion: (1) cellular microrobots (biologically actuated) that exclusively consist of cell-made components, and are precision-engineered to exhibit anticancer effects21, (2) synthetic microrobots22 (chemically and/or physically actuated) that contain only man-made materials, structures and components, and (3) hybrid microrobots, consisting of both artificial and cell-made components that can be propelled by biological or artificial means (usually biologically actuated)."

​
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology

Magnetic Microbots to Fight Cancer

Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow

Surgical Robot Successfully Navigates Itself Through Heart

Poem: from constant changes figure 

CD47 Protein:

• ​The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

The world's first "living" robot just got an upgrade
Gen1:

1. Scientific American
   • Autonomous: "the beating of heart tissue in specific parts of their “bodies” propelled the ‘bots through water in a petri dish for days, and even weeks at a stretch, without needing additional nutrients, according to the study"
   • Applications: "might include targeting toxic spills or radioactive contamination, collecting marine microplastics or even excavating plaque from human arteries, Levin said in a statement." 
     

Gen2:

1. ​Tufts Today

From a public Facebook group: The lighter side of science

Scientists want to 3D print bones in your body:
The technique is called the ceramic omnidirectional bioprinting in cell-suspensions