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Microrobots for Cancer Treatment

6/26/2021

 
Engineering Microrobots for targeted cancer therapies from a medical perspective
  • "To overcome low targeting of conventional treatments, two major strategies exist that aim to achieve tumour-specific effects: systemic drugs that only affect cancer cells, and drugs that are specifically delivered into the tumour cells and/or their microenvironments. "
  • "By contrast, solid tumours develop a higher-order tumour anatomy11, leading to different physical and biochemical microenvironments in the interior and exterior compartments (Fig. 2b). The increased requirement of oxygen of proliferating tumour cells is usually met by additional vascularisation to the exterior compartment of the tumour. Poor vascularisation inside the core region of the tumour, however, leads to a highly hypoxic core12,13. Low partial oxygen pressures force cancer cells residing in this area to generate energy via anaerobic, glycolytic pathways that lead to lactic acid generation and thus, acidic conditions inside the tumour core14. Moreover, owing to increased proliferation, limited space combined with abnormal blood and lymphatic networks increases the internal interstitial fluid pressure inside a tumour as it continues to grow, making it increasingly difficult to penetrate15."
  • "nanocarriers can be coupled with targeting ligands including peptides, proteins, antibodies or aptamers2. The ligands recognise surface markers on cancer cells and can increase the active short-range targeting abilities of nanocarriers."
  • "Cancer-fighting microrobots can be split into three major classes that can be distinguished based on their make-up and source of propulsion: (1) cellular microrobots (biologically actuated) that exclusively consist of cell-made components, and are precision-engineered to exhibit anticancer effects21, (2) synthetic microrobots22 (chemically and/or physically actuated) that contain only man-made materials, structures and components, and (3) hybrid microrobots, consisting of both artificial and cell-made components that can be propelled by biological or artificial means (usually biologically actuated)."
​
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology

Magnetic Microbots to Fight Cancer

Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow

Surgical Robot Successfully Navigates Itself Through Heart

DiffuserCam

1/2/2021

 
  1. Project Page
    • Dr.Laura talks about computational microscopy
  2. Hyperspectral imaging​
  3. Single Shot 3D imaging
    1. Single-shot 3D wide-field fluorescence imaging with a Computational Miniature Mesoscope
  4. Fluorescence Imaging
  5. Two-photon excitation microscopy

Photoinitiator

11/14/2020

 

AC VS. DC

9/8/2020

 

Contactless Data Transmission

6/18/2020

 
  • That's how WiFi works
    • Radio Wave: from radar to receiver (GHz: 1GHz=1 billion waves/second )
      • 2.4-5 GHz/sec
  • Radio Waves transmit information under water
    • Actually, radio waves can penetrate water 
    • A survey of underwater wireless communication technologies

Specific Volume

6/16/2020

 
As specific volume juts a reciprocal of density, why specific volume is used more often specifically in Thermodynamic? Some reasons that I have gathered from people:
  • Use properties like () per mass more than () per volume

How to design a screw on CAD for 3D print

6/9/2020

 

Why you have to boil pasta in hot water but rice in cold water

6/9/2020

 
  • Dried pasta can be boiled either in cold or warm water but hot water is easier for timing
    • There are two processes: hydration and gelatinization
      • ​Hydration is primarily for dry pasta​
        • ​once the hydrated starches reach a certain temperature they gelatinize
        • "gelatinization":Starch gelatinization is a process of breaking down the intermolecular bonds of starch molecules in the presence of water and heat, allowing the hydrogen bonding sites (the hydroxyl hydrogen and oxygen) to engage more water. This irreversibly dissolves the starch granule in water.
      • " Mixing most starches in warm water produces a paste, such as wheatpaste, which can be used as a thickening, stiffening or gluing agent. "
  • Rice can be cooked in either as well but putting in cold water is better
    • Simmer
Works Cited:
  • Starch gelatinization
  • Starch

ISS

6/1/2020

 
  • How does the ISS work​
  • How does NASA docking system work?
Picture

Satellites

6/1/2020

 
Satellite sounded like a very familiar topic for me, but I didn't​ realize how little I knew about it until my team in marine energy started a conversation about undersea cable communication.
  • ​A very good introductory video to satellite 
    • Types of Satellites
      • Navigation Satellite
        • Global Navigation Satellite System (GNSS)
          • Global Positioning System (GPS)
      • Weather Satellite
      • Communication Satellite
        • Phone, radio, internet, ..
  • Why is SpaceX making Starlink
    • Optical Fiber Communication 
Picture
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-- Aldous Huxley, Brave New World 
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